Alkaloids derived from the tropano, in smaller proportion than the belladona (0,20-0,45%): hiosciamina, atropine, escopolamina (more of 33% of the total alkaloids), norescopolamina.
Farmacológica Action
The atropine and the hiosciamina have a parasimpaticolítica action: antispasmodic, antiasthmatic, midriática, cardioaceleradora (although to low doses bradicardia causes one paradoxical), it elevates of moderate form the arterial tension, by increase of the peripheral resistance. The gastrointestinal peristaltismo diminishes. It produces a paralysis of uréteres. The gastric, pancreática, sudoral secretion diminishes and to salivar. The atropine is broncodilatadora (nevertheless it does not inhibit the production of broncoespasmos of histamínico origin). It is the analgesic premises. The escopolamina, more abundant alkaloid in estramonio, has sedative action on the central nervous system, considering itself like antiparkinsoniano.
Indications
It was used like antiparkinsoniano, antispasmodic and like the analgesic premises.
Due to the high toxicity of the alkaloids that contains, he is preferable not to use it in alopáticas doses.
Precaution/Poisonings
All the plant is toxic, with action similar, but more violent, than the belladona.
In low doses the poisoning attends with somnolencia, alterations of the vision, loss of sensitivity. To greater doses: cólicos pains, extreme midriasis, hallucinations, delirium and vertigos.
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