Abundant polisacáridos (45%): beta-D-glucana, arabinogalactanas; ganoderanas To, B and C. Triterpenos: ganodéricos acids To, B, C, D, F, H, K, M, R, S and and; ganodermadiol, derived from lanostaoico acid. Steroids: ganodosterona. Acidos greasy insaturados: oleic. Plans of alkaloids. Prótidos: Ling Zhi-8; glycoproteins (lectinas). Minerals: germanium, calcium.
Farmacológica Action
The polisacáridos ones of high molecular weight present/display a inmunoestimulante, antitumorlike action (power the production of citocinas by the macrophages and lymphocytes T and increases the levels of interleucina IL-1beta, IL-2 and IL-6, factor of tumorlike necrosis alpha and liberation gamma the interferon), antiviral (specially of preventive form), antinociceptiva and hipoglucemiante (indirect effect and precautions see). The triterpenos are responsible for their antiinflammatory, hipolipemiante action (it reduces the triglicéridos cholesterol levels and), antihypertensive and hepatoprotectora (action reinforced by ganodosterona): it has been verified that reishi produces a antifibrótico effect on the liver (it reduces the content of hepático colágeno, standardizes the altered hepática structure and it reduces to the aspartato levels transaminasa (AST), alkaline alanina transaminasa (ALT), GOT, lactodeshidrogenasa (LDH), fosfatasas and bilirrubina total). Antihistamine, by the action of ganodéricos acids and oleic. In addition
a plaquetario and relajante effect has been described muscular antiagregante.
Indications
Acute and chronic hepatitis, hepática cirrhosis. Helping in the prevention and treatment of oncológicos processes. Arterial hypertension, hiperlipidemias, arteriosclerosis, prevention of tromboembolismos. Helping in the treatment of the diabetes. Treatment of bottom of allergic processes. Inflammations osteoarticulares, muscular mialgias, contracturas. Also its effectiveness like helping has been verified experimentally in the treatment of the immunodeficiencies induced by abuse of opiate.
Indirect effect
Initially a descompensación in the glucose levels can be produced, that usually are standardized after weeks (it see section of precautions).
Precaution/Poisonings
When he prescribes himself to patients with diabetes, the doctor will have to control glucemia to fit, if it is necessary, the doses of insulin or the oral antidiabetics.
When it is prescribed to patients with dispepsias to hiper or hyposecretory, we recommended its postprandial administration, associate to demulcentes tisanes (for example malvavisco, malva or manzanilla).
Galénicas Forms/Dosage
Dust: 3 to 9 g/día, in two to three takings.
Bibliography
Chen RY; Yu DQ. Studies on the triterpenoid constituents of the spores from Ganoderma lucidum karst. Yao Hsueh Hsueh Pao, 26:267-73, 1991.
Chen WC; Hau DM; Wang CC; Lin IH; Read SS. Effects of ganoderma lucidum and krestin on subset T-cell in spleen of gamma-irradiated mice.
A.m. J Chin Med, 23:289-98, 1995
Chen TW; Wong YK; Read SS. In vitro cytotoxicity of Ganoderma oral lucidum on cancer cells. Chung Hua I Hsueh Tsa Chih (Taipei), 48:54-8, 1991 Jul.
Chen WC; Hau DM; Read SS. Effects of Ganoderma lucidum and krestin on to cellular immunocompetence in gamma-ray-irradiated mice. A.m. J Chin Med, 23:71-80, 1995.
Gau JP; Lin CK; Read SS; Wang MR. The lack of antiplatelet effect of crude extracts from ganoderma lucidum on HIV-positive hemophiliacs.
A.m. J Chin Med, 18:175-9, 1990.
I have And; Li R; Chen Q; Lin Z; Xia D; Ma L. Chemical studies on immunologically activates polysaccharides of Ganoderma lucidum(Leyss. ex- Fr.) Karst. Chung Kuo Chung Yao Tsa Chih, 17:226-8, 256, 1992 Apr.
Hsu HY; Lian SL; Lin CC. Radioprotective effect of Ganoderma lucidum (ex- Leyss.. Fr.) Karst to after X-ray irradiation in mice. A.m. J Chin Med, 18:61-9, 1990.
Kawagishi H; Mitsunaga S; Yamawaki M; Gone M; Shimada A; Kinoshita T;
Murata T; Usui T; Kimura A; Chiba S. To lectin from mycelia of the fungus Ganoderma lucidum. Phytochemistry, 44:7-10, 1997 Jan.
Koyama K; Imaizumi T; Akiba M; Kinoshita K; Takahashi K; Suzuki A; Yano S; Horie S; Watanabe K; Naoi And Antinociceptive components of Ganoderma lucidum. It plants Med, 63:224-7, 1997 Jun.
Kim RS; Kim HW; Kim BK. Suppressive effects of Ganoderma peripheral lucidum on proliferation of blood mononuclear cells. Mol Cells, 7:52-7, 1997 Feb 28.
Read SY; Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum:inhibition of sympathetic outflow ace to mechanism of its hypotensive action. Chem Pharm Bull (Tokyo), 38:1359-64, 1990 May.
Lin CN; Take WP; Won SJ. Novel cytotoxic principles of Formosan Ganoderma lucidum. J Nat Prod, 54:998-1002, 1991 Jul-Aug.
Lin JM; Lin CC; Chiu HF; Yang JJ; Read SG. Evaluation of the anti-inflammatory and liver-protective effects of anoectochilus formosanus, ganoderma lucidum and gynostemma pentaphyllum in rats. A.m. J Chin Med, 21:59-69, 1993.
Lin JM; Lin CC; Chen MF; Ujiie T; Takada To Radical to scavenger and antihepatotoxic activity of Ganoderma formosanum, Ganoderma lucidum and Ganoderma neon-japonicum. J Ethnopharmacol, 47:33-41, 1995 Jun 23.
Lieu CW; Read SS; Wang SY. The effect of Ganoderma lucidum on induction of differentiation in leukemic U937 cells. Anticancer Head of cattle, 12:1211-5, 1992 Jul-Aug.
Park EJ; Ko G; Kim J; Sohn DH. Antifibrotic effects of to polysaccharide extracted from Ganoderma lucidum, glycyrrhizin, and pentoxifylline in rats with cirrhosis induced by biliary obstruction. Biol Pharm Bull, 20:417-20, 1997 Apr.
Tao J; Clinical Experimental Feng KY and studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ, 10:240-3, 1990.
Wang SY; Hsu MILILITER; Hsu HC; Tzeng CH; Read SS; Shiao MS; Ho CK.
The anti-tumor effect of Ganoderma lucidum is mediated by cytokinesreleased from activated macrophages and T lymphocytes. Int J Cancer, 70:699-705, 1997 Sea 17.
Yun TK; Kim SH; Lee YS Trial of to new medium-term model using benzo(a)pyrene induced lung tumor in newborn mice. Anticancer Head of cattle, 15:839-45, 1995 May-Jun.
Zhang LX; Mong H; Zhou XB. Effect of Japanese Ganoderma Lucidum on production of interleukin-2 from murine splenocytes. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih, 13:613-5, 582, 1993 Oct
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