It is a shrub or a imperecedero shrub and can in the middle come heights from fifteen to twenty feet
The fruit seems a green grenade and it is covered with the reddish brown holes of the seed that give a aterronada texture him.
The fruit of noni begins green, yellow of the returns, mature to the whiteness and falls of the tree.
The tree has been to the fruits all the round year. Once a fruit is chosen, a new one will take its place after only three months!
The fruit of noni, in its crude form tastes bad scent and
Originated in India, now it grows in the several parts of the world such as Polynesian French and America Center (it is known that the best one is of Panama and islands of the Pacifico like Tahití, Hawaii, suroriental Asia)
Possible in volcanic ash rich enmineral grows the more better.
. The earliest reference to noni that it is used because a medicine dates from several thousands of years of the writings of Sanskrit of India when it was used in the medicine of Ayurvedic.
. Noni is used in the native medicinal systems of the islands of the Pacific of the south and power station, including Tahití, Samoa, Tonga and Hawaii, Malaysian suroriental Asia for example and the Philippines. Although knowledge is but extensive, he is polynesians French that really did noni to the part of their cultural life.
. Noni was, and continues being, prescribed by the curadores polynesian native to the pain convite, inflammation, burns, problems of the skin, intestinal worms, nausea, nutritional paste, fevers, intestine and menstrual, mordeduras problems etc. of the insect and the animal.
. The used parts include the crust, leaves, flowers, fruit and seeds.
. Noni was introduced to early the western world in the twentieth century.
. According to the Dr Neil Solomon, who considers a leader recognized in the nutrition and by naturistas, noni has disclosed to be safe for and embarazado/o mothers of the nurse office. Noni can also be taken with all medications and other supplements from the food.
. He is not addictive.
. The juice of TAHITIAN NONI? it is had including in edition 2003 of the reference of the doctors
Nutraceuticals
. On 150 nutraceuticals has been in the fruit of noni, some of those identified are: antraquinonas, betacaroteno, calcium, acid linoleic, magnesium, pectina, potassium, proline, protein, proxeronine, proxeroninease, scopoletin, beta-beta-sitosterols, esteroles, phenylalanine and tyrosine, acid ursolic, all the vitamins and the antirust ones of B have vitamin taste
C, proanthocyanadins and anthocyanadins.
How noni works? (and porqué can be good for so many conditions)
. Our work of the bodies by biochemical reactions. The examples include the increasing hair, to digest the food, curativas injuries, infections that fight, walking, thought, sensation and etc.
. There are certain processes in our body that are primary and of support of the whole body. Any change in these primary processes can cause dramatic changes through our whole body and of other aspects of our life.
. Two of main the primary processes include the processes of the synthesis and the communication.
. The synthesis includes all the things that our bodies do, for example, conectivos proteins, fine weaves, new cells, hormones, DNA etc.
. The communication refers to the flow of the controlled chemical intelligence between the cells, for the coordinated growth appropriate of the human body in its totality.
. The globular proteins are workhorses for the processes of the synthesis (enzymes) and the communication (receiving of the cell wall).
. The globular proteins are long filaments of the amino acids connected like grains in a sequence. Great and wobbly, happens very short only awhile in the exact form that does most of its predicted work.
More on proteins...
. The enzymes catalyze each biochemical reaction in the body and the receivers of the cell wall are responsible for much of the communication that happens biochemical in the body.
. In order to increase the effectiveness of an enzyme or a receiver, our bodies produce a small molecule called xeronine
that it is coined between filaments of the protein, doing it more rigid and therefore spending more time in his
efficient biochemical configuration.
. Dr Ralph Heinicke, a biochemist of the investigation, initiated the study of the Xeronine alkaloid. Xeronine takes place in the heavy internal body
Nuestros bodies contain all these blocks but proxeronine can be scarce.
. Under usual circumstances, the liver stores proxeronine, releasing in the blood the every two hours.
. The additional amount of proxeronine required comes from the food that we eat.
. Nevertheless the earth exhaustion & the environmental degradation have reduced the amount of components of xeronine in our food.
. Also diseases, aging, énfasises, extremely active etc. of life styles have placed a demand increased in proteins in our body.
. In order to increase the provision of xeronine in our body, proxeronine will more need to be provided by our diet.
. Noni is to contain, in the abundant amount, the components for xeronine, to knowing proxeronine & the enzymes needed to turn proxeronine xeronine, known as it proxeronase.
. One of the first scientists in investigating noni was the Dr Ralph Heinicke.
5 main Uses of Noni:
1, Daily tonic - it can be taken other supplements along with, inclusively vitamins, the minerals & grass, including: pycnogenal, germanium, vitamins C & E, chondroitin, etc. of side of áloe.
- It increases to the general health & the performance.
- the Dramatic improvement in debilitated conditions.
- the Increased absorption, the vitamin assimilation, use, the grass & the minerals.
- the Powerful function of anti-oxidant for the protection of the free radical damage.
2. Analge'sico - For the treatment of the pain & the headaches.
- the tree of noni also knows itself like "el Dolor & Arbol de Dolor cabeza".
- Beneficial for the back & the pain neck, muscular & the pain nerve, migraña & the headaches the tension.
- a 1990 study lead in the Laboratory of Pharmacosny of the University of Finds in France found noni to have a central effect of analgesic.
- According to studies informed in the daily Medica Plant (Analgesic and Effects of Behavourial de Morinda Citrifolia; Pág 430-434; October 1990), noni has been to be as effective 75% as morphine sulphate to alleviate the pain without the poisonous effects of the morphine side. Desemejante morphine, noni is not addictive.
3. The immune Support according to clinical tests lead by Dr Schechter, the director of Natural the Curativo Institute in California,
- Noni stimulates the production of T-CELULAS in the immune system. The T-cells play an essential role in the disease fighter.
- the acts of Noni to increase the immune system that implies macrophages and/or the lymphocytes, that are an essential part of the natural defenses of the body.
- Noni has been to fight many types of bacteria.
- Noni is a anticancerigenic one, inhibits the growth of tumors of the cancer allowing the abnormal cells to work more normally.
4. Antiinflamatorio - Effective for muscular and the conjunctures they condition as arthritis, syndrome of carpiano tunnel.
- the Reduction of the pain and swelling itself in hurt such as the bruises, the efforts and the burns.
- Beneficial for ulcers, cellulitis, the conditions of hair, itching the sarpullidos ones.
- It uses like a cataplasm, applied to the affected skin.
5, Adaptogen (Standardizing the Function)
- Aid to recover internal organs of body to the normal function.
- the Scientific documentation of benefits for the gastrointestinal system (diarrea, acidity, nausea, the colitis, the ulcers), reproductive organs (the menstrual problems, the leavening fibromas, infections), the liver & the páncreas (mellitus of diabetes, pancreatitis), respiratory system (the asthma, the sinusitis, enfisema), system of endocrino (thyroid & the suprarrenal disease), cardiovascular system (the disease of heart, the high tension, the blow) & nervous system (the emphasis, the depression, the memory, the sexual appetite, the energy).
- the Isolation of the enclosure of noni called scopoletin by the University of Hawaii in 1993 attributes the new enclosure to lower to the tension, reducing inflammation, killing bacteria & the fungi & preventing the growth of the tumor.
- phytonutrient, damnacanthal, found in noni, were found to be an inhibitor of some cells of precancerous. The reference: "la Induction of normal phenotypes in cells of evenness-transformed by damnacanthal of citrifolia of Morinda" Hiramatsu T, ET to. 75:161-166 Of Letters (1993) of cancer
Antibacteriano, antimicótico and agent of antiparasitic
. With the presence of active components it wants anthraquinones, scopoletin & terpenes (by example beta-carotene & the acid of ursolic), noni is effective against bacteria and the fungus.
. The damnacanthal extracts, one of the enclosures of anthraquinone has been to kill the parasite responsible for malaria called Plasmodium falciparum. The reference: The Medical Parasitology, the C.V. the Company of Mosby, London (1971)
. Damnacanthal is also powerful against leishmaniasis, a condition of parasite.
. Another enclosure of anthraquinone called alizarin inhibits the virus (VIH) human of immunodeficiency. The reference: "las inhibiting activities of Antiretroviral of anthraquinones and their effects in transcriptase inverso" Hirotaka H, ET to. Investigation (1991) 15(3):205-216 antiviral
. Noni exhibited the vigorous action of antiparasitic when an alcoholic extract that consists of citrirolia of morinda & other plants were proven in the human worm of lumbricoides parasite called Ascaris. The reference: "la Investigation of indigenous plants for the human action of anthelmintic con lumbricoides of Ascaris: II" Dismisses; Pharmacol (1975) Indian of Physiol J 19: stranger
. The investigators of the Philippines informed that a concentration of noni leaves killed 89% of tuberculosis of Mycobacterium, the bacteria that cause tuberculosis. The investigators identified the active enclosures in the plant of noni to be steroids of plant, or phytosterols. The reference: isolated Potential "agentes of antimycobacterial of the leaves of noni" Greet J, ET to. International the Chemical Congress of Pacific Societies of Palangana, Honolulu (2000)
About Dr Ralph Heinicke
. Ralph Heinicke graduated as the University of Cornell in 1936 with a special interest in the plant physiology. After to complete his studies in electrical engineering in the University of Kentucky, Lexington, it happened to receive his Ph.D. in the biochemistry of the University of Minnesota. It lived in Hawaii from 1950 to 1986, making investigation for the Company of Fragmentation hand grenade of Unemployment, for the Institute of Investigation of Fragmentation hand grenade, and for the University of Hawaii.
. The Origins of Xeronine - the first passage in its discovery of the active ingredients of the fruit of citrifolia of Morinda was in its work in the Company of Fragmentation hand grenade of Unemployment. It was to comisionar to find the medicinal uses for an enzyme that was predominant in the fragmentation hand grenade, bromelain. Dr Heinicke published articles in several scientific newspapers that detail the findings of their investigation. Ever since about 1972, Dr Heinicke had been trying to identify the ingredient unknown in bromelain, that he believed was truely responsible for the encouraging results of his clinical work. After many years of investigation, it possibly identified this ingredient like a new alkaloid to that it gave the name "xeronine." In December 1981, he patented xeronine like a new alkaloid.
The Footpath Takes to Morinda Citrifolia - Because it was convinced of the potential benefits like result of his investigation, joint Dr of Heinicke was to find a food source that was high in proxeronine (the precursor to xeronine) that could be used like a food supplement. Living in Hawaii, he had heard of the many reclamations that had become about the M. plants of citrifolia, so he chose the fruit of this plant like the subject of his search for a supplement of xeronine. He discovered that this plant not only contains enormous amounts of proxeronine, the precursor to xeronine, but that he also contains he proxeronase of the enzyme that facilitates the conversion of proxeronine to xeronine in the body.
. Dr Heinicke has spent most of his life in the study of M. citrifolia and the nature of his healthful properties, inclusively xeronine and proxeronine. "He worked directly with laboratory of Morinda to continue the investigation that I began in the healthful properties of M. citrifolia, inclusively xeronine and their precursor, proxeronine. Morinda harvests M. exclusively citrifolia of French Polynesia, the source of best quality M. citrifolia with the highest levels of proxeronine of any fruit in mundo".
The source: Heinicke, R.M. and Levand, Or, the Acido de Ferulic like a Component of a Complex Polymer of Carbohydrate of Bromelain, Vol de Phytochemistry. 7, 1968, págs. 1659 to 1662.
Heinicke, R.M. and Gortner, W. To, Tallo Bromelain -- a New Preparation of Protease of the Fragmentation hand grenade Plant, Economic Botany 11, 1957, pp 225-234.
Register in the registry of literary property * 1999. Reserved well. This only is for the distribution in the U.S.A.. This is not for the sale to by minor nor for the use in other countries where this document has not been approved. This information can be copied and been able to be distributed freely.
How to take NONI
When a new consumer of NONI, must drink at least 3 months to do an exact decision for is it the effectiveness in its body. All body is different. Some noticed people are like result as soon as few while the others later do not see a change until several months. Déle a right opportunity to work.
. Drink the abundance of water before & after to drink juice of noni to help the body it absorbs the juice & even toxins of the system. Smoothly shake the bottle before drinking. Mézclelo with water or its favorite juice of fruit if you wish (does not reduce the effectiveness of the juice).
. NONI: The Juice can be taken daily like a supplement to help to maintain the health good.
Phase I Study of Noni in Cancer Patients
This study is currently recruiting patients.
Sponsored by
National for Center Complementary and Alternative Medicine (NCCAM)
Purpose
The purpose of this Phase 1 study is to: 1. determines the maximum tolerated dose of capsules containing 500mg of freeze dried noni fruit extract, 2, defines toxicities associated with the ingestion of noni, 3, collect preliminary information on the efficacy of noni in respect to anti-tumor and symptom for control properties to help select specific patients subsequent Phase 2 studies, 4, identify chemical constituents of the extract that dog be used to characterize the bioavailability and pharmacokinetics of noni food supplement.
Condition
Treatment or Intervention
Phase
Neoplasms
Neoplasm Metastasis
Drug: Noni Extract
Phase I
MedlinePlus related topics: Cancer; Cancer Alternative Therapy
Study Type: Interventional
Study Design: Treatment
Further Study Details:
This Phase I study of noni in cancer patients represents to first step in the systematic study of Complementary and Alternative Medicine (CAM) practices that draw on Asian and Pacific cultural Island traditions of healing to control to cancer and its related symptoms. Noni, extracted from Morinda citifolia or the Indian mulberry plant, is included in the traditional pharmacopoeias of Native Hawaiians, to other Pacific Islanders and Asian populations, and you have been used to treat various diseases for hundreds of years. It is now commonly taken by to cancer patients based on purported usefulness in the disease although there is little scientific evidence to to either support or refutes these claims. To large marketing enterprise and AT least elevates different suppliers supports the food supplement's popularity. The broad long range objectives which this study will initiate plows to defines the usefulness of noni extracts for to cancer patients. The hypothesis to be tested is that noni AT to specified dosing prograpevines to cancer patients with to sufficient benefit to toxicity procases out to be useful ace to therapeutic. Specific aims of this study plows: 1. Maximum determines the tolerated dose of capsules containing 500mg of freeze-dried noni fruit extract. 2. Associated defines toxicities with the ingestion of noni. 3. Collect preliminary information on the efficacy of noni in respect to anti-tumor and symptom for control properties to help select specific patients subsequent Phase II studies. 4. Chemical Identify constituents of the extract that dog be used to characterize the bioavailability and pharmacokinetics of noni food supplement.
Eligibility
Genders for Eligible Study: Both
Criteria
Patients must:
Have to pathologically or cytologically verified diagnosis of to cancer and evidence of disease for which nonstandard treatment is available;
Be ambulatory, CAPABLE of self care, and up and about dwells than 50% of waking hours;
Have completed all to other to cancer treatments AT least four weeks previously;
Have any been on medications considered by to their physician to be essential to to their health (e.g. lipid lowering, antidiabetic, antihypertensive) AT consistent dosing AT least four weeks prior to starting noni;
Agree to take not to other CAM treatments while taking noni and agree to keep to diary, recording all medications taken daily, including all non prescription products and to record the Time that noni is taken.
Location and Contact Information
Faith Inoshita, RN, MS 808-586-2979 faithi@crch.hawaii.edu
Hawaii
University of Hawaii, Cancer Research Center, Honolulu, Hawaii, 96813, United States; Recruiting
Main Study chairs or investigators
Brian F. Issell, Md, FRACP, Main Investigator, University of Hawaii
Information Dwells
Study YOU GO Numbers 1 R21 AT00896-01
Study Start Date November 2001; Estimated Completion Date June 2003
Record last reviewed April 2004
NLM Identifier NCT00033878
ClinicalTrials.gov processed this record on 2004-05-12
U.S. National Library of Medicine, Contact NLM Customer Service
National Institutes of Health, Department of Health & Human Services
Copyright, Privacy, Accessibility, Freedom of Information Act
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