LOVELIA (lobelia inflata)

	L
	LOVELIA
	*lobelia inflata*

Name
LOVELIA

Scientific Name
lobelia inflata

LOVELIA

Used Part

The leaves.

Active Principles

A twenty of alkaloids of the type of the piperidina and metilpiperidina are had isolated, most important of which it is the lobelina. They are to also emphasize the lobelanina and the lobelanidina.

Farmacológica Action

It has a adrenérgica action (simpaticomimética): it increases the frequency and it forces of the cardiac beat, it acts like coronariodilatadora, it diminishes the peristaltismo and it increases the tone intestinal. It causes liberation of hepático glycogen, it inhibits the biliary secretion, it diminishes the diuresis, he is vasoconstrictor, it increases the tension arterial. When producing adrenalínica unloading, stimulates the central nervous system at level of the centers bulbares, producing broncodilatación. The isolobinina has a balsamic, expectorante and antiasthmatic effect.

Indications

Asthma, chronic bronchitis, enfisema, respiratory insufficiency (like urgency medication). By its gangliopléjico effect similar to the nicotine (it acts like antagonist), its use in the nicotínica deshabituación was praised.

Contraindications

Arterial hypertension, pregnancy, lactancia. Not to prescribe simultaneously neurolépticos nor to other drugs with alkaloids.

Precaution/Poisonings

It is a very toxic plant (DL = 4g): it can produce vomits, diarrea, hypotension, tachycardia and, next, bradicardia, followed anxiety of stupor, convulsions and death by respiratory paralysis.

Due to the differences in the composition of the plant based on its origin, he is more recommendable to use standardized, valued forms in the isolated or semisynthetic lobelina, or alkaloids.

Galénicas Forms/Dosage

- It tinctures (1:10): 100-300 mg, one to three times to the day. Maximum permissible dose = 3 g/día.

- micronizado Dust: 50 to 300 g, one to three times to the day. Maximum permissible dose = 1.5 g/día.

Bibliography

Benigni, R; Capra, C; Cattorini, P. Piante Medicinali. Chimica, Farmacologia and Terapia. Milano: Inverni & Della Beffa, 1962, pp. 867-80.

Bézanger-Beauquesne, L; Pinkas, M; Torck, M. You plant dans to Them the Therapeutique Moderne. 2ª. Paris: Maloine, 1986, pp. 274-5.

Bézanger-Beauquesne, L; Pinkas, M; Torck, M; Trotin, F. Plantes Médicinales DES Regions Tempérées. Paris: Maloine, 1980, p.350.

British Herbal Pharmacopoeia. Vol. I. Bournemouth, Dorset: British Medical Herbal Association, 1990, p. 63.

Bruneton, J. Elementos de Fitoquímica and Farmacognosia. Zaragoza: Acribia, 1991, pp.398-401.

D'Arcy, PF. Adver reactions and interactions with herbal medicine. Part II. Drug interactions. Adver Drug React Toxicol Rev, 1993; 12 (3): 147-162.

James, A; Duke, Ph D. Handbook of Medicinal Herbs. 5ª. Mouth Mouse, Florida: CRC Press, 1987, pp.280-1; 520; 559.

Paris, RR; Moyse, M. Précis de Matière Médicale. Take III. Paris: Masson, 1971, pp. 301-6.

Peris, JB; Stübing, G; Vanaclocha, B. Applied Fitoterapia. Valencia: M.I. Official school of Phamacists, 1995, pp. 350-1.

Samuelsson, G. Drugs of Natural Origin. To Textbook of Pharmacognosy. Stockholm: Swedish Pharmaceutical Press, 1992, p. 247.

Simón, R. Gui'a de Farmacologi'a for Phamacists and Doctors. Madrid: To Madrid Vicente, 1993, p. 59.

Trease, GE; Evans, WCh. Farmacognosia. Mexico D.F.: Inter-American -- MacGraw-Hill, 1991, pp. 623-5.

Hellemont, J. Compendium de Phytotherapie go. Bruxelles: Association Pharmaceutique Belge, 1986, pp. 237-8.

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